Metabolic Syndrome: The Overlooked Silent Killer

Metabolic Syndrome

Weight-related conditions that increase risk for heart disease, type 2 diabetes, and certain cancers

Metabolic syndrome is a group of obesity-linked conditions, including high blood pressure, elevated blood sugar, excess abdominal fat, and abnormal cholesterol or triglyceride levels that together triple the risk of cardiovascular disease and double the risk for type 2 diabetes.

Despite affecting nearly 1 in 3 U.S. adults, it’s largely underdiagnosed because risk factors are evaluated individually rather than in combination.

Support your Metabolic Syndrome with a personalized weight loss plan.

Why it matters

Metabolic syndrome is a cluster of conditions that significantly increases the risk of heart disease, type 2 diabetes, and other serious health complications. Certain groups are at higher risk, including individuals with obesity, those with type 2 diabetes or a family history of the condition, and people with mental health conditions such as schizophrenia, bipolar disorder, or depression. Risk is also elevated among females—especially those with a history of polycystic ovarian syndrome (PCOS)—as well as tobacco smokers and individuals with chronic drug or alcohol use.

Bridging risk and results

Metabolic syndrome is diagnosed when a person meets three or more of the following criteria: a waist circumference greater than 40 inches in men or 35 inches in women, triglyceride levels of 150 mg/dL or higher, HDL cholesterol below 40 mg/dL in men or 50 mg/dL in women, blood pressure of 130/85 mm Hg or higher, and fasting glucose of 100 mg/dL or higher. Weight loss and intensive lifestyle behavioral therapy are effective strategies for reducing risk and helping prevent or manage the condition.

Impact Beyond the Scale

Real Patients. Real Results.

Behind every pound is a parent with more time for their kids, a patient taking fewer medications, a person rediscovering confidence and joy.

*Estimates based on published research: Type 2 diabetes (PMID: 11832527); cardiovascular events (PMID: 22753554); obesity-related cancers (CDC); life-years gained (PMID: 16287956); healthcare cost savings (CDC).